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Structuraly, Semax is an analog of the ACTH(4–10) fragment ( Met-Glu-His-Phe-Pro-Gly-Pro) , while Selank is a derivative of the immune molecule tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

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In addition, glutamic acid 46 (E46) and arginine 72 (R72) of HLA class II are essential for a stable interaction between Gp2 and MHC-II, where R72 is conserved in all HLA-DR,-DP alleles, but E46 is conserved in all HLA-DR,-DP alleles and only in a small subset of HLA-DQ alleles: β * 02 (β * 0201, β * 0202, and β * 0203) [219–221]